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For Jacob H. Carruthers, knowledge is always linked to power. In fact, he contended that knowledge is always constructed within the ontology of the culture in question. Which means that the production of knowledge is inextricably linked to the structural and to the epistemological foundations of a society. Carruthers contrasted the Kemetic ideal of divine speech to the European praxis of fundamental alienation. He would argue that this difference of worldview carried with it enormous ramifications for the production of knowledge and the organization of societies. This essay seeks to explicate Carruthers’ varied discourse on knowledge, worldview, and power. It offers an analysis of his work as a compelling site of cultural critique and African-Centered knowledge production, which continues to inform our ongoing conceptualization of Africana Studies as a liberatory enterprise.